报告时间：2025年9月1日（星期一）15:00-17:00
报告地点：昇华楼616会议室
报 告 人：René Michael Koenigs 教授
工作单位：亚琛工业大学、拜罗伊特大学
举办单位：化学与化工学院，高值催化转化与反应工程安徽省重点实验室，安徽省柔性智能材料创制与应用工程研究中心
报告简介：
Photochemistry offers unique opportunities for reaction discovery by enabling the generation and control of highly reactive intermediates under mild conditions. Our research explores how visible-light activation can unlock novel reactivity modes of species such as carbenes, radicals and nitrenes, providing access to previously unattainable bond constructions and heterocyclic frameworks. This approach highlights photochemistry as a powerful platform for advancing modern synthetic methodology.
Herein, we present our recent advances in photochemical and photocatalytic carbene and nitrene transfer reactions. Emphasis will be placed on strategies to access either singlet or triplet states and how this electronic control enables distinct applications in synthetic methodology. Approaches to modulate nitrene reactivity via single-electron transfer pathways or direct photoexcitation will be highlighted, supported by mechanistic and computational studies that have guided the discovery of advanced cycloaddition chemistry.
We further outline an international, collaborative research program that integrates fundamental reactivity studies, reaction development, and mechanistic insight with translational applications in drug discovery. This work demonstrates how photochemical methods can unlock the potential of reactive intermediates and convert fundamental discoveries into new strategies for the synthesis of therapeutic candidates. Together, these studies highlight photochemistry as a powerful driver of innovation at the interface of fundamental and applied research.
报告人简介：
René Michael Koenigs（雷内-麦克-柯尼希斯）教授，博士毕业于德国亚琛工业大学。2015年加入亚琛工业大学有机化学研究所，任助理教授，2022年-至今为教授。2025年4月加入拜罗伊特大学，任教授，有机化学方向主任。主要研究方向为卡宾和氮宾转移反应及其应用。Koenigs教授入选安徽省外国专家人才项目（Anhui Province Foreign Expert Talent Program, 2025），荣获澳大利亚研究委员会未来研究员计划（Australian Research Council Future Fellowship, 2023）；亚琛工业大学FAMOS卓越领导力奖（RWTH Aachen FAMOS award for excellence in leadership, 2021）。相关研究成果在Science、Nature Commun、Angew. Chem. Int. Ed.等期刊发表。